From Little Rock, AR
Take I-30 from Little Rock. Continue on I-30 until it becomes I-530. Travel 35.0 on I-530 until it becomes US-65 in Pine Bluff. Continue on US-65 – for 90 miles. You will arrive at the intersection of US-65 and US-82 in Lake Village, AR. Continue on US-82 – for 10 miles. Cross the Mississippi River Bridge. Once you cross the Mississippi River Bridge, MS-454 will be on your right. Turn right on MS-454 and travel 5.2 miles. Arrive at MS-454 and US-1 in Greenville, MS. Turn right on US-1 and make an immediate left on County Rt 174. Blues Festival signs will be posted.

From Memphis, TN
Take US-61 south off 240 bypass and continue on US-61 for 131 miles. Take the US-82 West exit towards Leland/Greenville and travel 0.4 miles. Continue on US-82 west travel go 9.3 miles. Turn left on US-1 (intersection of US-1 and US-82) south travel 5.8 miles. Arrive at MS-454 at US-1 South, Greenville.

From Birmingham, AL
Take I-20 west/I-59 south towards Tuscaloosa (I-65) travel 54.0 miles. Take exit #71B towards Tuscaloosa onto I-359 north, travel 2.2 miles. I-359 north becomes AL-69 north, travel 3.0 miles. Turn left on US-82 west - go 76.3 miles. Take ramp onto US-82 WEST - go 141.1 miles. Turn left on US-1 (intersection of US-1 and US-82) south and travel 5.8 miles. Arrive at MS-454 at US-1 South, Greenville.

From Jackson, MS
Take I-20 west to I-220 north. Travel 6.0 miles to US-49 north. Continue on US-49 north for 32.4 miles. Turn left on US-49W and travel18.4 miles. Turn left on MS-14 travel14.2 miles. Turn Right on US-61 and travel 22.3 miles. Turn Left on MS-438 and travel 9.6 miles. Turn Right on MS-1 and travel 3.3 miles. Arrive at MS-454 at US-1 South, Greenville.